Dr. Rashmi Pal, Dr. Seema Dwivedi, Dr. Garima Gupta, Dr. Divya Dwivedi, Dr. Vineeta Singh and Dr. Tanu Midha
Background: Natural or spontaneous menopause is a transition period in a woman's life from the reproductive to the non-reproductive phase. It happens with the final menstrual period, which is known to happen after 12 months of amenorrhea with no obvious pathological or physiological causes.1,2 It promotes aging and hastens the progression of non-communicable diseases. Menopause occurs between the ages of 45 and 55 worldwide.2 Menopause symptoms manifest not only in the female genital tract, but also in the skeletal, cardiovascular, and psychological systems. With rising life expectancy, women are more likely to experience long periods of menopause, accounting for roughly one-third of their age. As a result, the morbidity burden has increased.
Aim and Objectives: To compare the effects of lifestyle modification with & without isoflavones supplementation for menopausal symptoms.
Methods: The study was conducted in Department of Obstetrics and Gynaecology, Upper India Sugar Exchange Maternity Hospital, GSVM Medical College in Kanpur of Uttar Pradesh state. This hospital is a tertiary care teaching hospital. The study was conducted in obstetrics department of the hospital. Postmenopausal women who had at least 1 year history of cessation of menses were included. Availability of subjects for the entire study period and willingness to adhere to protocol requirements as evidence by written informed consent. Perimenopausal females of age >40 years. Perimenopausal is the period immediately prior to and up to 1 year after the final menstrual period.
Conclusion: The present study was a triple arm randomized clinical trials study conducted to determine the comparative analysis of effect of lifestyle modification with and without Isoflavanis for menopausal symptoms was performed at the department of Obstetrics and gynaecology, Upper India Sugar Exchange Maternity Hospital, GSVM Medical College, Kanpur. The following are the important conclusion drawn from the study. In our study majority of the women were 50 - 69 years age group from urbon population and housewives in occupation in all three groups respectively. In our study majority of the patients had normal BMI and blood pressure in all groups Isoflavanis life style modification and lifestyle Isoflavanis respectively. In our study Vasomotor symptoms psychological and urogenital symptoms reduce after the lifestyle dietary and yoga with Isoflavane and intervention which is shown by reduction in MRS score after the intervention. The results of the present study strongly recommend lifestyle modification dietary supplementation yoga and Isoflavane supplementation resulted in reduction of menopausal symptoms. Thus importance of life-style management yoga and Isoflavane to be incorporated in daily routine under the supervision and motivation / adherence can be mandatory. The mean, Vasomotor symptoms were significantly lower in lifestyle mod which Isoflavane group III group at 2nd visit and 3rd visit. In our study regarding the safety profile of phyto-estrogen Isoflavane no majoride effect, were found and only minor side effect like headache, nausea, vomiting were present. No breakthrough bleeding (every women with hormone therapy).
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